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KMID : 0385019990150030251
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Korean Journal of Laboratory Animal Science
1999 Volume.15 No. 3 p.251 ~ p.255
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Effects of Green Tea Extract and Its Components on the Brain Neurotransmitters in ICR Mice
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이희용/Lee, Hee Yong
최성진/이혜숙/이호섭/양승돈/조애리/송창우/Choi, Sung Jin/Lee, Hye Suk/Lee, Ho Sub/Yang, Sung Don/Cho, A Ri/Song, Chang Woo
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Abstract
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The effects of given tea extract and its three components including caffeine, theanine and catechins on the brain acetylcholine, catecholamines and 5-hydroryindoles in IC8 mice were investigated. Following a single oral administration of green tea extract, brain dopamine (DA) and serotonin (5-HT) levels showed increase tendancy, and homovanilinic acid (HVA) was significantly increased. Catechin administration significantly increased brain DA and norepinephrine (NE) levels, but significantly decreased choline level. Theanine significantly increased DA and acetylcholine levels. Caffeine treatment significantly increased brain 5-HT, 5-hydroxy-indoleactic acid (5-HIAA), DA, 3,4-dihydroryphenylacetic acid (DOPAC), HVA, and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels. The formation of DOPAC and HVA from DA and MHPG from NE was increased by caffeine administration. In conclusion, an oral administration of green tea extract or its constituents such as catechins, caffeine and theanine caused neurochemical changes in brain.
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